InVivoMAb anti-mouse MAdCAM-1
The MECA-367 monoclonal antibody reacts with mouse MAdCAM-1 (mucosal addressin cell adhesion molecule-1) a 50-60 kDa member of the Ig superfamily. MAdCAM-1 is primarily expressed on high endothelial venules in Peyer's patches, mesenteric lymph nodes and gut lamina propria. MAdCAM-1 interacts with LPAM-1 and CD62L to facilitate lymphocyte tethering, rolling, and homing. The MECA-367 antibody has been shown to block the interaction of MAdCAM-1 with its receptor in vivo and in vitro.
|Recomended Isotype Control(s)||InVivoMAb rat IgG2a isotype control, anti-trinitrophenol|
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 7.0 Dilution Buffer|
Endothelial cells isolated from BALB/c mouse
0.2 μM filtered
Purified from tissue culture supernatant in an animal free facility
Undiluted at 4°C in the dark