May 28, 2020
Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
Bio X Cell Charitable Fund
May 18, 2020
The Bio X Cell Charitable Fund was originated as an employee-driven philanthropy fund with a mission to give back to our community.
InVivoMAb anti-mouse TIGIT
May 7, 2020
Applications for in vivo TIGIT stimulation and Flow cytometry
- Under The Hood
Bio X Cell Opens New Doors
April 24, 2020
We have moved into our new Bio X Cell headquarters!
TIGIT limits immune pathology during viral infection
April 9, 2020
Immune checkpoint proteins play a fundamental role in regulating T cell responses during viral infections. On one hand, they need to promote T cell functions in order to clear the virus. On the other hand, they need to restrict T cell activity to prevent immunopathology. Understanding the effects of these checkpoint inhibitors could result in the development of novel therapies to treat viral infections.
FGL-1 is a major inhibitory receptor of LAG-3 and its blockade can potentiate anti-tumor T cell responses
April 8, 2020
Lymphocyte-activation gene 3 (LAG-3) is a receptor that negatively regulates the proliferation, activation, and effector function of T cells. Currently, monoclonal antibodies that block the interaction of LAG-3 with its canonical ligand, MHC-II, are being evaluated for their antitumor activity in clinical trials.
InVivoMAb anti-mouse FGL-1
April 7, 2020
For in vivo and in vitro FGL-1 blockade, Flow cytometry, and Immunohistochemistry
InVivoMAb anti-rat/mouse CD71 (TfR1)
March 9, 2020
In need of an anti-rat/mouse transferrin receptor antibody?
InVivoMAb anti-mouse CD69
February 18, 2020
For in vivo down-regulation of CD69 expression and Functional assays
February 17, 2020
Check out what’s been happening at Bio X Cell.
Photo by Julius Drost on Unsplash
Targeting sphingolipid metabolism enhances cancer immunotherapy
February 11, 2020
This study identifies SK1 as a “checkpoint lipid kinase”, able to modulate immune escape mechanisms. Clinical strategies based on combining SK1 inhibition and immune checkpoint inhibition may improve the response rate in patients affected with melanoma or other malignancies.
Supporting our Chinese Partners Fighting the Corona Virus
February 7, 2020
A recent outbreak of a respiratory illness caused by a novel strain of coronavirus (2019-nCoV) was first detected in Wuhan City, Hubei Province, China. Health officials confirmed over 31,000 infected individuals and more than 600 deaths in China (New York Times, 7 February 2020). “Infections with 2019-nCoV, most of them associated with travel from Wuhan, […]
- Under The Hood
Team Building with Bio X Cell
February 4, 2020
The culture of a work environment has everything to do with employee retention, productivity, performance, engagement, revenue, and emotional and physical wellbeing.
- Under The Hood
An Inside Look at Our Future Space
February 4, 2020
The Bio X Cell team is excited to move to our new, eco-friendly building in Spring 2020!
The Bio X Cell Charitable Fund
January 31, 2020
In keeping with Bio X Cell’s long-standing tradition of giving, we have established an employee-driven Bio X Cell Fund, via the New Hampshire Charitable Foundation.
Life Science Exhibits – University of Florida and University of South Florida
January 29, 2020
At the end of January, Bio X Cell team members Cody and Lauren headed down to sunny Florida to attend two Research Supplier Product Shows. The first was held January 22nd at University of Florida Gainesville, and the second took place January 23rd at University of South Florida in conjunction with Moffitt […]
InVivoMAb anti-mouse CD71 (TfR1) (Clone: 8D3)
January 21, 2020
Transport your research to the next level using Bio X Cell’s anti-mouse CD71 antibody
History of Bio X Cell
January 7, 2020
Klaus began Bio X Cell with the goal of furthering scientific research in both the private and public sectors. More than 20 years later, we are proud to be continuing that mission. For that reason, Bio X Cell will continue to offer our products at the same unmatched prices in 2020. We take pride in offering the highest quality, USA-made products at the lowest industry prices. We value our customers and the work they are doing to advance research science.
Skin resident neutrophils protect against MRSA infection
December 12, 2019
Staphylococcus aureus is a common bacterium carried on the skin of up to 50% of the population. Carriage of S. aureus is typically asymptomatic however, it is responsible for 76% of all skin and soft tissue infections and can cause fatal invasive infections.
- Under The Hood
Tour of Asia
December 3, 2019
This autumn, Klaus Lubbe, our CEO, traveled to Asia where he met with four distributors: Neobioscience, Tokyo Future Style, IWAI Chemicals and BioCLONE. While traveling in the region, Klaus also attended two conferences, IUIS 2019 in Beijing, China and KAI in Seoul, Korea.
InVivoMAb anti-mouse CD28 (Clone: D665)
November 25, 2019
The D665 monoclonal antibody reacts with mouse CD28, a 45 kDa costimulatory receptor and a member of the Ig superfamily.
November 11, 2019
As November sets in, we start to reflect on what 2019 has brought us. We are truly grateful for you!
Targeted CD103+ CD8 T cell depletion prolongs the survival of diabetic mice
November 6, 2019
Type 1 diabetes is caused by the destruction of insulin producing β cells by the immune system. Islet cell transplantation therapy represents a viable therapeutic approach for treating type 1 diabetes. This approach requires the use of immunosuppressive drugs to avoid islet rejection.
InVivoMAb anti-human IL-9 (Clone: MH9A4)
November 4, 2019
The MH9A4 monoclonal antibody reacts with human IL-9, a pleiotropic cytokine expressed by Th9 cells, Th2 cells, Th17 cells, regulatory T cells, NKT cells, ILC2s, and mast cells. IL-9 promotes mast cell and T cell proliferation, stimulates mast cell accumulation in tissues, promotes ILC survival, enhances class-switching to IgE in B cells and alters haematopoietic progenitor cell activity.
The Korean Association of Immunologist International Meeting 2019
October 27, 2019
Bio X Cell attended the Korean Association of Immunologists (KAI) International Meeting 2019. This meeting took place on October 30th-November 1st at the Sejong University Convention Center in Seoul, Korea.
International Union of Immunological Societies (IUIS)
October 16, 2019
Bio X Cell is thrilled to be an exhibitor at the upcoming 17th Annual Congress of Immunology (IUIS 2019)!
October 10, 2019
This month, members of the Bio X Cell team will be heading to China to attend the 2019 International Congress of Immunology (IUIS 2019) in Beijing.
Boston FOCIS 2019 Annual Meeting
October 8, 2019
Bio X Cell is a proud sponsor of the 2019 Federation of Clinical Immunology Societies’ (FOCIS) Annual Meeting which took place June 18th -21st in Boston, MA.
Yale Immunobiology Retreat 2019
September 25, 2019
Cody Spencer, Ph.D. represented Bio X Cell at the 2019 Yale Immunobiology Retreat located at The Norwalk Inn and Conference Center in Norwalk, CT.
Optimizing anti-4-1BB agonistic antibodies for cancer immunotherapy
September 20, 2019
Immune checkpoint blocking antibodies have gained great success in the clinic however, these treatments are effective for only about 30% of patients. Most of these antibodies block co-inhibitory molecules like PD-1 and CTLA-4 but the development of agonistic antibodies against co-stimulatory molecules has lagged behind.
Discover if IL-27 plays a role in your research
September 3, 2019
InVivoMAb anti-mouse IL-27 p28 is used for in vivo IL-27 p28 neutralization, in vitro IL-27 p28 neutralization, and Flow cytometry.
Fighting cancer with antibodies and philanthropy
August 13, 2019
Bio X Cell’s August Newsletter
Longwood Medical BioResearch Product Faire
July 30, 2019
Come chat with Klaus or Cody, from the Bio X Cell team, for a chance to win a pair of Beats Studio3 Wireless over-ear headphones!
July 25, 2019
The Prouty is the signature event of The Friends of Norris Cotton Cancer Center whose mission is to raise money and awareness for this nationally recognized cancer facility. NCCC has 15 locations throughout New Hampshire and Vermont to reach patients close to home.
Does type I collagen play a role in your research?
July 22, 2019
The XL313 monoclonal antibody reacts with denatured human and mouse collagen type-I but not native collagen type-I. The antibody reacts with the RGD motif.
Just. Pure. Antibodies.💧and July News
July 12, 2019
Check out the exciting news happening with BIo X Cell
University of Pittsburg BioResearch Product Faire
July 1, 2019
Cody Spencer, PhD, Bio X Cell’s Senior Scientist was excited to showcase all of our products on Friday, June 28th, 2019.
11th Annual Block Party Supporting Norris Cotton Cancer Center
June 27, 2019
Bio X Cell felt honored to co-host the 11th Annual Block Party in Lebanon, on Thursday, June 27th, 2019, to support the Norris Cotton Cancer Center and the Prouty!
Does TL1A-DR3 signaling play a role in your research?
June 18, 2019
The 5G4.6 monoclonal antibody reacts with the TNF family member TL1A, also known as TNFSF15. TL1A is expressed on activated T cells, dendritic cells, monocytes, and endothelial cells.
June’s Latest and Greatest
June 14, 2019
To have this monthly blog update emailed directly to you, signup for our monthly newsletters. You will also receive one-of-a-kind monthly product promotional discount codes for our Featured Product of the month!
Prophylactic treatment with antagonistic anti-TNFα antibodies may improve outcomes of anti-PD-1 and anti-CTLA-4 combination cancer immunotherapy
June 10, 2019
The combination of anti-PD-1 and anti-CTLA-4 antibody-mediated immunotherapy is remarkably effective against melanoma, renal cell carcinoma, and non-small-cell lung cancer.
Does SIRPα play a role in your research?
May 28, 2019
The P84 monoclonal antibody reacts with Signal-Regulatory Protein α (SIRPα), also known as CD172a.
Cedarlane Life Science and Medical Lab Expo
May 22, 2019
Stop by and see Klaus and Tim on Thursday, May 23, 2019!
May 20, 2019
C O N G R A T U L A T I O N S to Yang Hu, PhD from The Forsyth Institute! He is our Beats Giveaway Winner!
InVivoMAb anti-mouse NKG2A/C/E
April 19, 2019
The 20D5 monoclonal antibody reacts with mouse NKG2A, NKG2C, and NKG2E also known as CD159a, CD159c, and CD159e respectively.
Welcome Cell Zion
April 9, 2019
Bio X Cell is pleased to welcome a new distributor to our family!
April 1, 2019
For the last five consecutive years, Bio X Cell has been attending the Annual Meeting for the American Association of Cancer Research. The AACR annual meeting is the largest of its kind in the world for cancer researchers, bringing together more than 18,000 researchers from over 60 countries every spring.
Deplete neutrophils in mice with InVivoMAb anti-mouse
March 27, 2019
Reported Applications: in vivo neutrophil depletion, Immunohistochemistry (paraffin), Immunohistochemistry (frozen), Immunofluorescence, Flow cytometry
Activation of ILC2 expressed GITR ameliorates type 2 diabetes
March 22, 2019
Chronic obesity is associated with the development of systemic inflammation and recruitment of inflammatory immune cells to tissues, such as adipose tissue, liver, and muscle. This pro-inflammatory environment promotes insulin resistance and the development of type 2 diabetes.
March into News, Research Highlights, and Savings with Bio X Cell
March 11, 2019
The global source for in vivo antibodies
The FasL and the Furious – Introducing anti-mouse Fas ligand (CD178)
March 5, 2019
The MFL3 monoclonal antibody reacts with mouse Fas Ligand (FasL) also known as CD178, CD95 Ligand, and TNFSF6. FasL is a 40 kDa type II transmembrane glycoprotein and a member of the TNF superfamily.
Melanoma tumors use IFNγ mutations to fight anti-CTLA-4 immunotherapy
March 2, 2019
Dr. Padmanee Sharma’s group at MD Anderson Cancer Center have discovered that tumor cells use genetic mutations which cause a loss of IFNγ signaling to resist the cancer drug ipilimumab. This study marks the first clearly defined resistance to ipilimumab identified in tumor cells.
How do I decide which anti-mouse PD-1 antibody is best for me?
February 8, 2019
Bio X Cell offers three different anti-mouse PD-1 monoclonal antibodies: Clones RMP1-14, 29F.1A12, and J43. All three of these antibodies are commonly used to block PD-1 signaling in vivo in murine tumor models and other mouse models. These three clones all have extensive multi-year publication records supporting them. References Although all three of these antibodies […]
Oxygen sensing by T cells facilitates the establishment of cancer metastasis in the lung
January 26, 2019
Dr. Nicholas Restifo’s group at the National Cancer Institute’s Center for Cancer Research have discovered that oxygen-sensing proteins, called prolyl hydroxylase domain (PHD) proteins, act within T cells to prevent overly strong immune responses to harmless particles that frequently enter the lung.
Bio X Cell’s Top 20
December 20, 2018
Bio X Cell invites you to view our top 20 BEST SELLERS of 2018!
- Under The Hood
December 19, 2018
MAY YOUR HOLIDAY SEASON BE MERRY AND BRIGHT!
Last Shipping Dates: Due to the upcoming holidays, the last shipping day prior to Christmas is December 21st.
VPR’s Membership Drive
December 18, 2018
Listener-supported Vermont Public Radio has been serving the people of Vermont and the surrounding region since 1977. As Vermont’s only statewide public radio network, VPR is a trusted and independent source for news, music, conversation, NPR programming, and much more.
A Novel Immune Checkpoint Inhibitor Anti-NKG2A Antibody Promotes Anti-Tumor Immunity by Unleashing Both T and NK Cells
December 13, 2018
Immune checkpoint inhibitors, in particular anti-PD-1/L1, have revolutionized cancer treatment over the past decade, providing long-lasting benefits.
Microbial Infection Induces Autoimmunity
November 30, 2018
Dr. Julie Blander’s group at the School of Medicine at Mount Sinai have discovered that during an infection that causes the apoptosis of infected cells, CD4+ T cells with specificity to self-antigens are activated along with CD4+ T cells specific to the infecting pathogen.
- Under The Hood
What’s your favorite pie?
November 16, 2018
Thanksgiving is less than a week away! It’s time to start baking!
Anti-CD47 antibodies counter cardiovascular disease
November 12, 2018
Nicholas J. Leeper’s group at the Stanford University School of Medicine have discovered that the signal that tumor cells display on their surfaces to protect themselves from being cleared by the immune system also plays a role in enabling atherosclerosis.
We Walk Brussels
November 9, 2018
To honor October as breast cancer awareness month, Bio X Cell was happy to support Think Pink in We Walk Brussels on October 20, 2018!
- Under The Hood
Pumpkin Carving at Bio X Cell
October 31, 2018
Happy Halloween from all of us at Bio X Cell!
Blocking messages carried through brain lymphatic vessels curbs the development of multiple sclerosis
October 25, 2018
Recently researchers at the University of Virginia, led by Jonathan Kipnis identified lymphatic vessels surrounding the brain, vessels that textbooks long insisted did not exist.
- Under The Hood
2018 Nobel Prize for Medicine
October 23, 2018
Bio X Cell congratulates Dr. Jim Allison & Tasuku Honjo for receiving the 2018 Nobel Prize for Medicine
Naïve T cells switch to one-carbon metabolism upon activation
September 21, 2018
Marcia C. Haigis’s group from the Department of Cell Biology at Harvard Medical School have discovered that CD4 T cell activation requires a unique program of mitochondrial biogenesisis.
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
September 6, 2018
The gut microbiota has been shown to play important roles in maintaining intestinal homeostasis.
LIGHT-HVEM signaling protects against enteric bacterial infection
August 23, 2018
It is known that ILCs in the small intestine play a protective role against several mucosal bacterial infections including Yersinia enterocolitica (YE) infection.
The program for central memory T cell generation is preserved intrinsically in CD8 T cells.
August 10, 2018
Eun Young Choi’s group from the Seoul National University College of Medicine have discovered that CD4 T cell help is not required to initiate differentiation of CD8 T cells into central memory T cells during an immune response.
TIGIT blockade prevents NK cell exhaustion and elicits potent anti-tumor immunity
July 20, 2018
TIGIT deficiency in NK cells is sufficient to delay tumor growth in vivo and blockade of TIGIT via monoclonal antibodies reverses the exhaustion of anti-tumor NK cells in multiple tumor models and improves overall survival.
July 14, 2018
On a weekend in July over 5,250 people gather in Hanover, NH. They’re gathering to bike, to row, to walk, to golf, to sponsor, to volunteer, and to support The Prouty, an annual two-day athletic event that benefits the Dartmouth-Hitchcock Norris Cotton Cancer Center (NCCC).
Regulatory T cells use lymphotoxin beta receptor to migrate from tissues to lymph nodes
July 10, 2018
Dr. Jonathan S. Bromberg’s group from the University of Maryland School of Medicine have discovered that Tregs preferentially express and use lymphotoxin αβ for migration to lymph nodes.
CD40 stimulation drives T cell immunity in cancer
July 1, 2018
Drs. Katelyn Byrne and Robert Vonderheide from the University of Pennsylvania have discovered that CD40 stimulation along with chemotherapy causes T cell-dependent destruction of pancreatic ductal adenocarcinoma (PDA).
May 4, 2018
For over a century the American Association of Immunologists (AAI) has been meeting annually. Founded on June 3rd, 1913, the AAI is an organization has grown to include over 8,000 members, including 25 Nobel Laureates, hailing from at least 71 different countries. Day by day the organization works to fulfill its mission “to promote by […]
March 29, 2018
Over 100 years ago a small group of scientists had a meeting. The setting was the Willard Hotel in Washington D.C.; there were 11 attendees. The group was comprised of researchers, pathologists, and surgeons, each was outstanding in their field and each sharing a common goal defeating cancer. Together they formed the American Association of […]