January 26, 2018
IL-4 produced by NKT cells is critical for the induction of B cell responses after viral infection
During viral infections B cells provide protection through the generation of class-switched antibodysecreting cells in germinal centers in lymph nodes and the spleen. This process is known to be regulated by T cells however, T cells arrive relatively late during the immune response. How B cells initially seed germinal centers is still unclear. NKT cells enhance the production of antibodies by B cells that are presenting glycolipid antigens. However, no reports of lipid antigens originating from viruses exist, therefore it is currently unclear whether NKT cells have a role in inducing antiviral B cell responses.
September 15, 2017
IL-2 and α-ketoglutarate-sensitive metabolic changes drive T cell differentiation gene programs
Dr. Amy S. Weinmann’s group from the University of Alabama have identified a mechanism by which changes in metabolism play a role in regulating T cell and possibly embryonic stem cell differentiation programs.