June 27, 2018

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

Leukemia stem cells (LSCs) are thought to drive acute myeloid leukemia (AML). Despite decades of research, effective therapies for AML remain extremely limited.

InVivoMAb anti-human CD3

January 26, 2018

IL-4 produced by NKT cells is critical for the induction of B cell responses after viral infection

During viral infections B cells provide protection through the generation of class-switched antibodysecreting cells in germinal centers in lymph nodes and the spleen. This process is known to be regulated by T cells however, T cells arrive relatively late during the immune response. How B cells initially seed germinal centers is still unclear. NKT cells enhance the production of antibodies by B cells that are presenting glycolipid antigens. However, no reports of lipid antigens originating from viruses exist, therefore it is currently unclear whether NKT cells have a role in inducing antiviral B cell responses.

InVivoPlus anti-mouse IL-4 InVivoMAb anti-mouse IL-4