InVivoMAb anti-mouse ICOS

Clone Catalog # Category
7E.17G9 BE0059 InVivoMab Antibodies
$95 - $3250
SDS Sheet

About InVivoMAb anti-mouse ICOS

The 7E.17G9 monoclonal antibody reacts with mouse ICOS (inducible T cell co-stimulator). ICOS is a 47-57 kDa homodimeric glycoprotein belonging to the CD28 family of costimulatory molecules. ICOS is expressed on activated T cells and upon ICOSL binding, co-stimulates T and B cell responses. The ligand Is expressed on antigen presenting cells including splenic B cells, dendritic cells, and macrophages. ICOS signaling is also thought to be important for maintaining regulatory T cell homeostasis. The 7E.17G9 antibody has been shown to block the binding of ICOSL to ICOS in vivo.

InVivoMAb anti-mouse ICOS Specifications

Isotype

Rat IgG2b, κ

Recommended Isotype Control(s) InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin(BE0090)
Recommended InVivoPure Dilution Buffer InVivoPure pH 8.0 Dilution Buffer(IP0080)
Immunogen

Mouse ICOS cDNA and ICOS hexahistidine fusion protein

Reported Applications
  • in vivo blocking of ICOS/ICOSL signaling
  • Flow cytometry
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 8.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

RRID

AB_1107622

References provided by Bioz:

Disclaimer: These articles are provided by Bioz, an automated third-party article search engine. Given Bioz’s automation, these articles may not reflect the reported applications listed for this product. For an extensive up-to-date article list directly tailored to the reported applications listed for this product please see the Bio X Cell Application References by clicking the green button above.


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