InVivoMAb anti-mouse/human IL-7

Clone Catalog # Category
M25 BE0048 InVivoMab Antibodies
$95 - $3250
SDS Sheet

About InVivoMAb anti-mouse/human IL-7

The M25 monoclonal antibody reacts with mouse and human IL-7, a 20-28 kDa hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. IL-7 is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells. IL-7 binds to the IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and the common gamma chain receptor. Binding results in stimulation of differentiation of pluripotent hematopoietic stem cells into lymphoid progenitor cells and proliferation of all lymphoid cells. IL-7 is also important for proliferation of pre-B cells as well as T and NK cell survival, development and homeostasis. The M25 antibody is useful for neutralizing the bioactivity of IL-7 as well as administration of IL-7 cytokine. IL-7 administration as a complex with M25 prolongs IL-7 availability in vivo by decreasing specific and nonspecific consumption.

InVivoMAb anti-mouse/human IL-7 Specifications

Isotype

Mouse IgG2b

Recommended Isotype Control(s) InVivoMAb mouse IgG2b isotype control, unknown specificity(BE0086)
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Recombinant human IL-7

Reported Applications
  • in vivo IL-7 neutralization
  • in vivo IL-7 receptor stimulation (as a complex with IL-7)
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

RRID

AB_1107711

References provided by Bioz:

Disclaimer: These articles are provided by Bioz, an automated third-party article search engine. Given Bioz’s automation, these articles may not reflect the reported applications listed for this product. For an extensive up-to-date article list directly tailored to the reported applications listed for this product please see the Bio X Cell Application References by clicking the green button above.


Powered by Bioz

We're Heading to AACR

Come visit us at Booth 1842! See you in Atlanta!