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InVivoMAb anti-mouse CD3ε
Clone Catalog # Category
145-2C11 BE0001-1 InVivoMab Antibodies
$300 - 3080

The 145-2C11 monoclonal antibody reacts with mouse CD3ε a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. CD3εis one of five polypeptide chains that combine to form the TCR complex. CD3εis expressed on T lymphocytes NK-T cells and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling T lymphocyte activation and antigen recognition. The 145-2C11 antibody has been shown to induce T lymphocyte activation proliferation and apoptosis via binding and stimulating the TCR. Additionally the 145-2C11 antibody has been reported to block the binding of the 17A2 antibody to CD3ε+ T lymphocytes.

Isotype

Armenian Hamster IgG1

Recomended Isotype Control(s) InVivoMAb polyclonal Armenian hamster IgG
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen

Mouse BM10-37 cytotoxic T cells

Reported Applications
  • in vivo T cell depletion
  • in vitro T cell stimulation/activation
  • Immunofluorescence
  • Flow cytometry
  • Western blot
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein A

Storage

Undiluted at 4°C in the dark