InVivoMAb anti-mouse CD38
About InVivoMAb anti-mouse CD38
The NIMR5 monoclonal antibody reacts with mouse CD38 a 42 kDa type II transmembrane glycoprotein. CD38 is expressed on immature and mature resting and activated B cells as well as NK cells and a subset of T cells. CD38 expression is down-regulated on mouse germinal center B cells and plasma cells. CD38 is a multifunctional protein involved in NAD homeostasis and in the generation of the second messengers ADPR and cyclic ADPR which are involved in intracellular calcium signaling. Antibodies against CD38 have been shown to be highly efficacious in the treatment of multiple myeloma. The NIMR5 antibody is reported as an agonistic antibody and has been shown to induce B cell proliferation, protect B cells from apoptosis, and slow disease progression in tumor-bearing mice.
InVivoMAb anti-mouse CD38 Specifications
Rat IgG2a, κ
|Recommended Isotype Control(s)||InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089)|
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 7.0 Dilution Buffer(IP0070)|
BCL1 plasma membrane glycoproteins
0.2 μM filtered
Purified from tissue culture supernatant in an animal free facility
Undiluted at 4°C in the dark
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