InVivoMAb anti-human/mouse denatured collagen type-I (RGD motif)

CloneCatalog #Category
XL313BE0324InVivoMab Antibodies
$95 - $3250

About InVivoMAb anti-human/mouse denatured collagen type-I (RGD motif)

The XL313 monoclonal antibody reacts with denatured human and mouse collagen type-I but not native collagen type-I. The antibody reacts with the RGD motif. Collagen is a fibrous multi-chain triple helical protein that exists in numerous forms. Collagen type-I is the most abundant collagen type in the extracellular matrix. Collagen type-I, type-III, collagen type-IV and collagen type-V have been shown to be associated with all pre-existing blood vessels in vivo. Denaturation of the native three-dimensional structure of collagen is thought to expose cryptic regulatory regions that control angiogenesis. The XL313 antibody has been shown to inhibit angiogenesis in chick embryos and enhance the anti-tumor activity of anti-PD-L1 therapy in vivo. XL313 administration has also been shown to inhibit Lewis lung carcinoma tumor growth in C57BL/6 mice (shown in US Patent No: 7588760B2).

InVivoMAb anti-human/mouse denatured collagen type-I (RGD motif) Specifications

Isotype Mouse IgG1, κ
Immunogen Synthetic RGD containing human collagen peptides
Reported Applications
  • Western blot
  • Immunofluorescence
  • in vivo administration (see description)
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Sterility 0.2 μM filtered
Production Purified from tissue culture supernatant in an animal free facility
Purification Protein G
RRID AB_2819051
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.