InVivoMAb anti-human Ganglioside GD2

Clone Catalog # Category
14G2a BE0318 InVivoMab Antibodies
$95 - $3250
SDS Sheet

About InVivoMAb anti-human Ganglioside GD2

The 14G2a monoclonal antibody reacts with human ganglioside GD2 a sialic-acid bearing glycolipid that is involved in mediating cell attachment to the extracellular matrix. Ganglioside GD2 is expressed on tumors of neuroectodermal origin including human neuroblastoma and melanoma. The tumor specific expression of GD2 makes it a suitable target for immunotherapy with monoclonal antibodies or with artificial T cell receptors. Clone 14G2a is an isotype switch variant selected from the parental IgG3-producing hybridoma 14.18 and has identical reactivity as the parental antibody.

InVivoMAb anti-human Ganglioside GD2 Specifications

Isotype

Mouse IgG2a, κ

Recommended Isotype Control(s) InVivoMAb mouse IgG2a isotype control, unknown specificity(BE0085)
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Neuroblastoma cell line LAN-1

Reported Applications
  • in vitro induction of apoptosis in GD2+ cells
  • in vivo inhibition of GD2+ tumor cell growth
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein A

Storage

Undiluted at 4°C in the dark

References provided by Bioz:

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