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InVivoMAb anti-mouse IL-12 p75
Clone Catalog # Category
R2-9A5 BE0233 InVivoMab Antibodies
$300 - 3080

The R2-9A5 monoclonal antibody reacts with mouse interleukin-12 (IL-12), a heterodimeric 75 kDa (p75) cytokine consisting of two covalently linked subunits, 40 kDa (p40) and 35 kDa (p35). IL-12 is secreted by activated monocytes, macrophages, dendritic cells and T cells in response to bacterial pathogens or products such as lipopolysaccharides (LPS). IL-12 is a potent regulator of cell-mediated immune responses and plays a key role in the development of Th1 responses, leading to IFNγ and IL-2 production. The R2-9A5 antibody has been shown to neutralize the biological effects of IL-12 when administered in vivo.

Isotype

Rat IgG2b

Recomended Isotype Control(s) InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin
Recommended InVivoPure Dilution Buffer InVivoPure pH 8.0 Dilution Buffer
Immunogen

Recombinant mouse IL-12 p75

Reported Applications
  • in vivo IL-12p75 neutralization
  • ELISA
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 8.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

Undiluted at 4°C in the dark