InVivoMAb anti-mouse IL-12 p75
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About InVivoMAb anti-mouse IL-12 p75
The R2-9A5 monoclonal antibody reacts with mouse interleukin-12 (IL-12), a heterodimeric 75 kDa (p75) cytokine consisting of two covalently linked subunits, 40 kDa (p40) and 35 kDa (p35). IL-12 is secreted by activated monocytes, macrophages, dendritic cells and T cells in response to bacterial pathogens or products such as lipopolysaccharides (LPS). IL-12 is a potent regulator of cell-mediated immune responses and plays a key role in the development of Th1 responses, leading to IFNγ and IL-2 production. The R2-9A5 antibody has been shown to neutralize the biological effects of IL-12 when administered in vivo.
InVivoMAb anti-mouse IL-12 p75 Specifications
Rat IgG2b, κ
|Recomended Isotype Control(s)||InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin(BE0090)|
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 8.0 Dilution Buffer(IP0080)|
Recombinant mouse IL-12 p75
0.2 μM filtered
Purified from tissue culture supernatant in an animal free facility
The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.