CONTRACT SERVICES

Bio X Cell offers custom fermentation and purification services for the production of monoclonal antibodies in cell culture. Bio X Cell employs state of the art fermentation technologies; including stirred tank fermenters and wavebag systems; our production capacity ranges from 5 to 500L.

Contract Production Of Antibodies

Bio X Cell provides production and purification services of antibodies produced from pre-existing hybridoma cell lines. These hybridomas are typically developed in the client’s laboratory or available in the public domain.

This service includes fermentation of the hybridoma in cell culture, harvest of the cell culture supernatant by centrifugation and concentration by 30 kDa ultrafiltration. Purification is performed by Protein A or G affinity chromatography. The purified antibody is dialyzed into PBS and filter sterilized. All of our custom products will be delivered with an endotoxin level < 2EU/mg. We also offer freezing of the cell line, on-site cell line storage and MAP testing for an additional fee.

All hybridomas submitted for contract production will first be evaluated in a small-scale pilot to determine whether the productivity is suitable to proceed to full scale. The fee for the pilot is $800 but will be waived if the production proceeds to full scale.

Pricing for 50 and 100 mg quantities is specified below. For information on contract production of quantities greater than 100 mg email customerservice@bxcell.com.

To begin, fill out and submit a Cell Line Information Form by clicking the button below. You will then receive a formal quote, and instructions for shipping cells.

PRICING

SIZE 50mg 100mg 200mg
ACADEMIC $1850 $2800 $4700
COMMERCIAL $2600 $4300 $7000
Fill out a Cell Line Information Form and Receive a Quote

Cell Line Information Form

  • **50mg Minimum**
  • **We will determine productivity within our system before moving to full scale, minimum is 20-30 mg/L**
  • If the isotype is unknown, Bio X Cell will determine the isotype for a $100 charge. It is necessary that we know the isotype in order to properly purify the antibody. Please check here to acknowledge this charge:
    • Assay S0034: Ultrasensitive qualitative detection of mouse hepatitis virus (MHV) by reverse transcription coupled real time PCR
    • Assay S0098: Ultrasensitive qualitative detection but not differentiation of mouse minute virus (MMV) and mouse parvovirus (MPV) by real time PCR
    • Assay S0099: Ultrasensitive qualitative detection of Sendai Virus (SEND) by reverse transcription coupled real time PCR
    • Assay S0102: Ultrasensitive qualitative detection of Theiler's murine encephalomyelitis virus by reverse transcription coupled real time PCR
    • Assay S0139: Ultrasensitive qualitative detection of pneumonia virus of mice by reverse transcription coupled real time PCR
    • Assay B0009: Ultrasensitive Mycoplasma screen by real time PCR. This screen detects but does not differentiate M. arginini, M. fermentans, M. hominis, M. hyorhinis, M. orale, M. pirum, M. salivarium, M. agassizii, M. cynos and others. This screen does not detect M. pneumoniae or M. pulmonis.
    • Panel P0029: Mouse Essentials Panel - Ultrasensitive detection and differentiation of the following pathogens using real time PCR protocols: MNV, MPV 1/2/3/4/5, MMV/MVM, MHV, REO-1, REO-2, REO-3, LCMV, LDV, MRV/EDIM, TMEV, ECTRO, HANTA, POLY, MAD1/MAV1, MAD2/MAV2, SEND, Mycoplasma pulmonis, PVM, mouse CMV, and K virus.

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