Neutrophils are the most abundant white blood cell in most mammals making up 40% to 75% of all circulating leukocytes. Playing an essential role in innate immunity neutrophils represent the body’s primary line of defense against invading pathogens such as bacteria. Neutrophils migrate to sites of inflammation following chemical gradients expressed by activated endothelium, mast cells, and macrophages. After reaching inflamed tissue neutrophils release cytokines, which in turn amplify inflammatory reactions by several other cell types. At the site of infection, neutrophils attack pathogens via phagocytosis, generation of reactive oxygen species, degranulation, and generation of neutrophil extracellular traps. Bio X Cell offers a variety of antibodies to facilitate neutrophil research including anti-Ly6G antibodies for neutrophil depletion, antibodies which block neutrophil adhesion and migration, and antibodies which neutralize neutrophil related cytokines and chemokines.
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