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Product Area of Research - Immune Checkpoint Proteins

Blockade of immune checkpoints is among the most promising approaches to activating therapeutic anti-tumor immunity. Immune checkpoints refer to inhibitory pathways that are crucial for maintaining self-tolerance in order to minimize collateral tissue damage. Tumor cells exploit certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumor antigens. Because many of these immune checkpoints are initiated by ligand-receptor interactions, they can be readily blocked by antibodies. Bio X Cell offers an extensive selection of immune checkpoint blocking antibodies including anti-PD-1, anti-CTLA-4, and anti-PD-L1. Our antibodies are highly pure with extremely low endotoxin levels and no preservatives or stabilizers added making them ideal for highly sensitive in vivo experiments.

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