InVivoMAb anti-mouse CD71 (TfR1)

Clone Catalog # Category
R17 217.1.3/TIB-219 BE0175 InVivoMab Antibodies
$95 - $3080
SDS Sheet

References provided by Bioz:


Powered by Bioz

About InVivoMAb anti-mouse CD71 (TfR1)

The R17 217.1.3/TIB-219 monoclonal antibody reacts with mouse CD71 also known as transferrin receptor protein 1 (TfR1). CD71 is a 170-180 kDa type II homodimeric transmembrane glycoprotein which is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors. CD71 plays a role in the control of cellular proliferation and is required for iron import from transferrin into cells by endocytosis. Due to its important role in proliferation and cellular iron intake as well as the fact that many cancerous cells express high levels of CD71 it is being explored as a potential new target in cases of human leukemia & lymphoma. The R17 217.1.3/TIB-219 antibody has been shown to deplete CD71+ erythroid splenocytes.

InVivoMAb anti-mouse CD71 (TfR1) Specifications

Isotype

Rat IgG2a, κ

Recomended Isotype Control(s) InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089)
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Mouse erythroleukemia cell line 745.6

Reported Applications

in vivo depletion of CD71+ cells

Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

RRID

AB_10950526