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InVivoMAb anti-mouse Vβ8 TCR
Clone Catalog # Category
F23.1 BE0182 InVivoMab Antibodies
$300 - 3080

The F23.1 monoclonal antibody reacts with the Vβ 8.1, Vβ 8.2, and Vβ 8.3 TCR (V beta 8.1-3 T cell receptors) of mice having the b haplotype of the Tcrb gene complex (e.g., AKR, BALB/c, C3H, C57BL, DBA/1, DBA/2). The TCR is expressed on the surface of T lymphocytes and is responsible for recognizing fragments of antigen as peptides bound to MHC molecules. When the TCR engages with antigenic peptide and MHC the T lymphocyte is activated through signal transduction. The F23.1 antibody has been shown to activate Vβ 8 TCR-expressing T lymphocytes, as well as block cytolysis mediated by Vβ 8 TCR-expressing cytotoxic T lymphocytes. Additionally, in vivo treatment of neonatal mice with the F23.1 antibody can arrest intrathymic maturation of Vβ 8 TCR-expressing T cells.

Isotype

Mouse IgG2a

Recomended Isotype Control(s) InVivoMAb mouse IgG2a isotype control, unknown specificity
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen

BALB.B Mouse lymph node and spleen T cells

Reported Applications

Flow cytometry

Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

Undiluted at 4°C in the dark