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InVivoMAb anti-mouse IFNγ
Clone Catalog # Category
R4-6A2 BE0054 InVivoMab Antibodies
$95 - $3080

The R4-6A2 monoclonal antibody reacts with mouse IFNγ (interferon gamma) a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. IFNγ is primarily produced by activated lymphocytes including T, B, NK cells, and ILCs. IFNγ exerts immunoregulatory, anti-proliferative, anti-viral, and proinflammatory activities and plays an important role in activation, growth, and differentiation of T and B lymphocytes, macrophages, NK cells and other non-hematopoietic cell types. Additionally, IFNγ induces the production of cytokines, Fc receptor, and adhesion molecules and up-regulates MHC class I and II antigen expression by antigen presenting cells during an immune response. IFNγ has also been shown to modulate macrophage effector functions, influence isotype switching and induce the secretion of immunoglobulins by B cells. IFNγ signals through the IFN gamma receptor which exists as a heterodimer composed of CD119 (IFNγ receptor 1) and AF-1 (IFNγ receptor 2). The IFNγ receptor is expressed ubiquitously on almost all cell types with the exception of mature erythrocytes. The R4-6A2 antibody has been shown to neutralize both natural and recombinant IFNγ.


Rat IgG1, κ

Recomended Isotype Control(s) InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase
InVivoMAb rat IgG1 Isotype control, anti-trinitrophenol
Recommended InVivoPure Dilution Buffer InVivoPure pH 8.0 Dilution Buffer

Partially-purified native mouse IFNγ

Reported Applications
  • in vivo IFNγ neutralization
  • in vitro IFNγ neutralization
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
  • >95%
  • Determined by SDS-PAGE
  • PBS, pH 8.0
  • Contains no stabilizers or preservatives

0.2 μM filtered


Purified from tissue culture supernatant in an animal free facility


Protein G


Undiluted at 4°C in the dark