InVivoMAb anti-mouse IL-6R

Clone Catalog # Category
15A7 BE0047 InVivoMab Antibodies
$95 - $3250
SDS Sheet

About InVivoMAb anti-mouse IL-6R

The 15A7 monoclonal antibody reacts with the mouse IL-6 receptor α chain also known as CD126. CD126 is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily. CD126 is expressed by activated T and B lymphocytes, monocytes, hepatocytes, and plasma cells. The IL-6 receptor α chain binds IL-6 but requires association with gp130 to initiate signal transduction. Upon IL-6 binding the IL-6R complex influences antigen-specific immune responses, inflammatory responses, neuronal development, and is a major mediator of the acute phase reaction. The 15A7 monoclonal antibody has been shown to block the binding of IL-6 to the IL-6 receptor.

InVivoMAb anti-mouse IL-6R Specifications

Isotype

Rat IgG2b, κ

Recommended Isotype Control(s) InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin(BE0090)
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

OKT-4 hybridoma cells

Reported Applications
  • in vivo blocking of IL-6/IL-6R signaling
  • in vitro blocking of IL-6R signaling
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein A High Salt

Storage

The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

RRID

AB_1107588

Molecular Weight

150 kDa

References provided by Bioz:

Disclaimer: These articles are provided by Bioz, an automated third-party article search engine. Given Bioz’s automation, these articles may not reflect the reported applications listed for this product. For an extensive up-to-date article list directly tailored to the reported applications listed for this product please see the Bio X Cell Application References by clicking the green button above.


Powered by Bioz

We're Heading to AACR

Come visit us at Booth 1842! See you in Atlanta!