InVivoMAb anti-mouse IL-6R
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About InVivoMAb anti-mouse IL-6R
The 15A7 monoclonal antibody reacts with the mouse IL-6 receptor α chain also known as CD126. CD126 is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily. CD126 is expressed by activated T and B lymphocytes, monocytes, hepatocytes, and plasma cells. The IL-6 receptor α chain binds IL-6 but requires association with gp130 to initiate signal transduction. Upon IL-6 binding the IL-6R complex influences antigen-specific immune responses, inflammatory responses, neuronal development, and is a major mediator of the acute phase reaction. The 15A7 monoclonal antibody has been shown to block the binding of IL-6 to the IL-6 receptor.
InVivoMAb anti-mouse IL-6R Specifications
Rat IgG2b, κ
|Recommended Isotype Control(s)||InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin(BE0090)|
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 7.0 Dilution Buffer(IP0070)|
OKT-4 hybridoma cells
0.2 μM filtered
Purified from tissue culture supernatant in an animal free facility
Protein A High Salt
The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.