InVivoMAb anti-mouse IL-10R (CD210)
Clone Catalog # Category
1B1.3A BE0050 InVivoMab Antibodies
$300 - 3080

The 1B1.3A monoclonal antibody reacts with mouse IL-10R (IL-10 receptor) also known as CD210. The IL-10R is a class II cytokine receptor and is expressed by a variety of cell types including thymocytes, T lymphocytes, B lymphocytes, NK cells, monocytes, and macrophages. Upon binding IL-10, IL-10R stimulation results in many pleiotropic, effects in immunoregulation and inflammation. IL-10R downregulates the expression of pro-inflammatory cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B lymphocyte survival, proliferation, and antibody production. IL-10R signaling can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. The 1B1.3A antibody is a neutralizing antibody and has been shown to block the binding of human IL-10, which cross-reacts with the mouse IL-10R. However, this clone does not recognize the human IL-10R.


Rat IgG1

Recomended Isotype Control(s) InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase
InVivoMAb rat IgG1 Isotype control, anti-trinitrophenol

Recombinant ligand-binding domain of mouse IL-10R

Reported Applications
  • in vivo blocking of IL-10/IL-10R signaling
  • in vitro blocking of IL-10R signaling
  • Flow cytometry
  • Western blot
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
  • >95%
  • Determined by SDS-PAGE
  • PBS + 0.01% Tween, pH 6.5
  • Contains no stabilizers or preservatives

0.2 μM filtered


Purified from tissue culture supernatant in an animal free facility


Protein G


Undiluted at 4°C in the dark