InVivoMAb anti-mouse CD86 (B7-2)
The GL-1 monoclonal antibody reacts with mouse CD86 also known as B7-2. CD86 is an 80 kDa Ig superfamily member. CD86 is expressed by activated T and B cells, macrophages, and dendritic cells. This ligand binds to CD28 to provide a costimulatory signal necessary for T cell activation and survival, and cytokine production. Additionally, CD80 binds to CTLA-4 which inhibits T cells. This antibody has been shown to block CD86 in vivo and inhibit the priming of cytotoxic T cells.
|Recomended Isotype Control(s)||InVivoMAb rat IgG2a isotype control, anti-trinitrophenol|
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 7.0 Dilution Buffer|
LPS-activated CBA/Ca mouse splenic B cells
0.2 μM filtered
Purified from tissue culture supernatant in an animal free facility
Undiluted at 4°C in the dark