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InVivoMAb anti-mouse CD86 (B7-2)
Clone Catalog # Category
GL-1 BE0025 InVivoMab Antibodies
$300 - 3080

The GL-1 monoclonal antibody reacts with mouse CD86 also known as B7-2. CD86 is an 80 kDa Ig superfamily member. CD86 is expressed by activated T and B cells, macrophages, and dendritic cells. This ligand binds to CD28 to provide a costimulatory signal necessary for T cell activation and survival, and cytokine production. Additionally, CD80 binds to CTLA-4 which inhibits T cells. This antibody has been shown to block CD86 in vivo and inhibit the priming of cytotoxic T cells.

Isotype

Rat IgG2a

Recomended Isotype Control(s) InVivoMAb rat IgG2a isotype control, anti-trinitrophenol
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen

LPS-activated CBA/Ca mouse splenic B cells

Reported Applications
  • in vivo CD86 blockade
  • Flow cytometry
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

Undiluted at 4°C in the dark