InVivoMAb anti-mouse CD25 (IL-2Rα)
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About InVivoMAb anti-mouse CD25 (IL-2Rα)
The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac. IL-2Rα is the 55 kDa ligand-binding subunit of the interleukin 2 receptor alpha chain. IL-2Rα is expressed on activated mature T and B lymphocytes, thymocyte subsets, pre-B cells, and T regulatory cells. IL-2Rα has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Alone, the IL-2Rα binds IL-2 with relatively low affinity however, when IL-2Rα associates with IL-2Rβ (CD122) and the common gamma chain (CD132) the complex binds IL-2 with high affinity. The PC-61.5.3 antibody has been shown to inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3 antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo.
InVivoMAb anti-mouse CD25 (IL-2Rα) Specifications
Rat IgG1, λ
|Recommended Isotype Control(s)||
InVivoMAb rat IgG1 Isotype control, anti-trinitrophenol(BE0290)
InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase(BE0088)
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 7.0 Dilution Buffer(IP0070)|
IL-2-dependent cytolytic mouse T cell clone B6.1
0.2 μM filtered
Purified from tissue culture supernatant in an animal free facility
Protein A High Salt
The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.