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InVivoMAb anti-mouse 4-1BB (CD137)

Clone Catalog # Category
LOB12.3 BE0169 InVivoMab Antibodies
$95 - $3080
SDS Sheet

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About InVivoMAb anti-mouse 4-1BB (CD137)

The LOB12.3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF- κB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growth in vivo when administered in combination with immune checkpoint inhibitors.

InVivoMAb anti-mouse 4-1BB (CD137) Specifications

Isotype

Rat IgG1

Recomended Isotype Control(s) InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase(BE0088)
InVivoMAb rat IgG1 Isotype control, anti-trinitrophenol(BE0290)
Recommended InVivoPure Dilution Buffer InVivoPure pH 8.0 Dilution Buffer(IP0080)
Immunogen

Mouse CD137 human Fc fusion protein

Reported Applications

in vivo activation of 4-1BB

Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 8.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

RRID

AB_10949016