InVivoMAb anti-mouse IL-7Rα (CD127)

Clone Catalog # Category
A7R34 BE0065 InVivoMab Antibodies
$95 - $3250
SDS Sheet

About InVivoMAb anti-mouse IL-7Rα (CD127)

The A7R34 monoclonal antibody reacts with mouse IL-7Rα also known as CD127. IL-7Rα is a 60-90 kDa type I transmembrane glycoprotein expressed on immature B cells, thymocytes, peripheral T cells, and bone marrow stromal cells. IL-7Rα forms a heterodimer with the common γ chain (γc or CD132) and upon ligation of IL-7 plays important roles in T and B cell development, and T cell homeostasis. Thymic Stromal Lymphopoietin (TSLP) also binds to IL-7Rα as a complex with the TSLPR chain to trigger activation of dendritic cells, and is also involved in B cell development, allergy and autoimmunity. The A7R34 antibody has been shown to block IL-7Rα signaling when administered in vivo.

InVivoMAb anti-mouse IL-7Rα (CD127) Specifications

Isotype

Rat IgG2a, κ

Recommended Isotype Control(s) InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089)
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

IL-7Rα-IgG1 fusion protein

Reported Applications
  • in vivo blocking of IL-7Rα signaling
  • Flow cytometry
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

RRID

AB_1107590

References provided by Bioz:

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