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InVivoMAb anti-mouse CD8 (Lyt 2.1)
Clone Catalog # Category
116-13.1 (HB129) BE0118 InVivoMab Antibodies
$350 - 3685

The 116-13.1 monoclonal antibody reacts with mouse CD8 also known as Lyt-2. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily expressed on the surface of cytotoxic T cells but can also be found on thymocytes natural killer cells and some dendritic cell subsets. CD8 most commonly exists as a heterodimer composed of one CD8╬▒and one CD8╬▓chain however it can also exist as a homodimer composed of two CD8╬▒chains. Both the CD8╬▒and CD8╬▓chains share significant homology to immunoglobulin variable light chains. The molecular weight of each CD8 chain is approximately 34 kDa. The 116-13.1 antibody exhibits depleting activity when used in vivo .

Isotype

Mouse IgG2a

Recomended Isotype Control(s) InVivoMAb mouse IgG2a isotype control, unknown specificity
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen

CE mouse spleen cells and thymocytes

Reported Applications
  • in vivo CD8+ T cell depletion
  • Flow cytometry
Endotoxin
  • <2EU/mg (<0.002EU/╬╝g)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 ╬╝M filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

Undiluted at 4┬░C in the dark