InVivoSIM anti-human VEGFR-2 (Ramucirumab Biosimilar)

CloneCatalog #Category
Ramucirumab SIM0012InVivoSIM Antibodies
$205 - $5575 Login for Academic & Non-profit Pricing

This product is for research use only, NOT FOR THERAPEUTIC USE (RUO).

About InVivoSIM anti-human VEGFR-2 (Ramucirumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Ramucirumab making it ideal for research use. This Ramucirumab biosimilar reacts with human VEGFR-2 (vascular endothelial growth factor receptor 2) also known as CD309, KDR, and Flk-1. VEGFR-2 is a member of the tyrosine protein kinase family. Upon binding to its ligand VEGF, VEGFR-2 pays key roles in vascular development and permeability. VEGFR-2 is expressed on endothelial cells at high levels in adult heart, lung, kidney, brain, and skeletal muscle as well as other tissues at lower levels. Ramucirumab binds to the extracellular domain of VEGFR-2 and blocks the binding of VEGFR ligands VEGF-A, VEGF-C and VEGF-D leading to inhibition of VEGF-mediated tumor angiogenesis.

InVivoSIM anti-human VEGFR-2 (Ramucirumab Biosimilar) Specifications

Isotype human IgG1
Immunogen Human VEGFR2
Reported Applications
  • Functional assays
  • Immunohistochemistry
  • Flow cytometry
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <1EU/mg (<0.001EU/μg)
  • Determined by LAL gel clotting assay
Aggregation
  • <5%
  • Determined by DLS
Purity
  • >95%
  • Determined by SDS-PAGE
Sterility 0.2 μM filtered
Production Purified from cell culture supernatant
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Test Results
  • Mouse Norovirus: Negative
  • Mouse Parvovirus: Negative
  • Mouse Minute Virus: Negative
  • Mouse Hepatitis Virus: Negative
  • Reovirus Screen: Negative
  • Lymphocytic Choriomeningitis virus: Negative
  • Lactate Dehydrogenase-Elevating Virus: Negative
  • Mouse Rotavirus: Negative
  • Theiler’s Murine Encephalomyelitis: Negative
  • Ectromelia/Mousepox Virus: Negative
  • Hantavirus: Negative
  • Polyoma Virus: Negative
  • Mouse Adenovirus: Negative
  • Sendai Virus: Negative
  • Mycoplasma Pulmonis: Negative
  • Pneumonia Virus of Mice: Negative
  • Mouse Cytomegalovirus: Negative
  • K Virus: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.