InVivoSIM anti-human IL-6R (Tocilizumab Biosimilar)

CloneCatalog #Category
Tocilizumab SIM0014InVivoSIM Antibodies
$205 - $5575 Login for Academic & Non-profit Pricing

This product is for research use only, NOT FOR THERAPEUTIC USE (RUO).

About InVivoSIM anti-human IL-6R (Tocilizumab Biosimilar)

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Tocilizumab making it ideal for research use. This Tocilizumab biosimilar reacts with human IL-6 receptor also known as CD126. IL-6R is an 80 kDa type I cytokine receptor and a member of the immunoglobulin superfamily. IL-6R is expressed by activated T and B lymphocytes, monocytes, hepatocytes, and plasma cells. The IL-6 receptor α chain binds IL-6 but requires association with gp130 to initiate signal transduction. Upon IL-6 binding the IL-6R complex influences antigen-specific immune responses, inflammatory responses, neuronal development, and is a major mediator of the acute phase reaction. Tocilizumab binds to both soluble and membrane bound IL-6R and blocks the binding of IL-6 to IL-6R.

InVivoSIM anti-human IL-6R (Tocilizumab Biosimilar) Specifications

Isotype human IgG1
Immunogen Human IL-6R
Reported Applications
  • Functional assays
  • ELISA
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <1EU/mg (<0.001EU/μg)
  • Determined by LAL gel clotting assay
Aggregation
  • <5%
  • Determined by DLS
Purity
  • >95%
  • Determined by SDS-PAGE
Sterility 0.2 μM filtered
Production Purified from cell culture supernatant
Purification Protein A
Molecular Weight 150 kDa
Murine Pathogen Test Results
  • Mouse Norovirus: Negative
  • Mouse Parvovirus: Negative
  • Mouse Minute Virus: Negative
  • Mouse Hepatitis Virus: Negative
  • Reovirus Screen: Negative
  • Lymphocytic Choriomeningitis virus: Negative
  • Lactate Dehydrogenase-Elevating Virus: Negative
  • Mouse Rotavirus: Negative
  • Theiler’s Murine Encephalomyelitis: Negative
  • Ectromelia/Mousepox Virus: Negative
  • Hantavirus: Negative
  • Polyoma Virus: Negative
  • Mouse Adenovirus: Negative
  • Sendai Virus: Negative
  • Mycoplasma Pulmonis: Negative
  • Pneumonia Virus of Mice: Negative
  • Mouse Cytomegalovirus: Negative
  • K Virus: Negative
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.