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InVivoPlus anti-mouse IL-17A

$ 390.00$ 4,000.00

SKU: BP0173 Categories: , ,
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References SDS Sheet

 

InVivoPlus anti-mouse IL-17A

Clone: 17F3 Catalog#: BP0173

Storage:Undiluted at 4C in the dark.
Production:Tissue culture
Isotype:Mouse IgG1
Purification:Protein G
Recommended Dilution Buffer:InVivoPure pH 7.0 Dilution Buffer
Recommended Isotype Control:MOPC-21
Reported Applications:In vivo IL-17A neutralization
Endotoxin: <1EU/mg (<0.001EU/μg)

Endotoxin level is determined using an LAL gel clotting test.
Aggregation: <5%Aggregation determined by DLS
Purity: > 95%Purity determined by SDS-PAGE.
Formulation: PBS, pH 7
Sterile: 0.2 µm filtration
Murine Pathogen Test Results: Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Minute Virus: Negative
Mouse Hepatitis Virus: Negative
Reovirus Screen: Negative
Lymphocytic Choriomeningitis virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Mouse Rotavirus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
Polyoma Virus: Negative
Mouse Adenovirus: Negative
Sendai Virus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Mouse Cytomegalovirus: Negative
K Virus: Negative

Description:

The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-17A in vivo.