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InVivoPlus anti-mouse CSF1R (CD115)

$ 390.00$ 4,000.00

SKU: BP0213 Categories: , ,

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References SDS Sheet

 

InVivoPlus anti-mouse CSF1R (CD115)

Clone: AFS98 Catalog#: BP0213

Storage:Undiluted at 4C in the dark.
Production:Tissue culture
Isotype:Rat IgG2a
Purification:Protein G
Recommended Dilution Buffer:InVivoPure pH 7.0 Dilution Buffer
Recommended Isotype Control:2A3
Reported Applications:In vivo macrophage depletion
in vitro CSF-R1 neutralization
in vivo monocyte depletion
Flow cytometry
Western blot
Endotoxin: <1EU/mg (<0.001EU/μg)

Endotoxin level is determined using an LAL gel clotting test.
Aggregation: <5%Aggregation determined by DLS
Purity: > 95%Purity determined by SDS-PAGE.
Formulation: PBS, pH 7
Sterile: 0.2 µm filtration
Murine Pathogen Test Results: Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Minute Virus: Negative
Mouse Hepatitis Virus: Negative
Reovirus Screen: Negative
Lymphocytic Choriomeningitis virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Mouse Rotavirus: Negative
Theiler’s Murine Encephalomyelitis: Negative
Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
Polyoma Virus: Negative
Mouse Adenovirus: Negative
Sendai Virus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Mouse Cytomegalovirus: Negative
K Virus: Negative

Description:

The AFS98 monoclonal antibody reacts with mouse colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115. CSF1R is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. In mice CSF1R is expressed by monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. CSF1R is a receptor for CSF1 and CSF1 signaling through CSF1R regulates the proliferation and differentiation of cells in the monocytic lineage. The AFS98 antibody has been reported to deplete macrophages and block CSFR1 in vivo.