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InVivoPlus anti-mouse IFN╬│
Clone Catalog # Category
XMG1.2 BP0055 InVivoPlus Antibodies
$390 - 4000

The XMG1.2 monoclonal antibody reacts with mouse IFN╬│ (interferon gamma) a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. IFN╬│ is primarily produced by activated lymphocytes including T, B, NK cells, and ILCs. IFN╬│ exerts immunoregulatory, anti-proliferative, anti-viral, and proinflammatory activities and plays an important role in activation, growth, and differentiation of T and B lymphocytes, macrophages, NK cells and other non-hematopoietic cell types. Additionally, IFN╬│ induces the production of cytokines, Fc receptor, and adhesion molecules and up-regulates MHC class I and II antigen expression by antigen presenting cells during an immune response. IFN╬│ has also been shown to modulate macrophage effector functions, influence isotype switching and induce the secretion of immunoglobulins by B cells. IFN╬│ signals through the IFN gamma receptor which exists as a heterodimer composed of CD119 (IFN gamma receptor 1) and AF-1 (IFN gamma receptor 2). The IFN╬│ receptor is expressed ubiquitously on almost all cell types with the exception of mature erythrocytes. The XMG1.2 antibody is a neutralizing antibody.

Isotype

Rat IgG1

Recomended Isotype Control(s) InVivoPlus rat IgG1 isotype control, anti-horseradish peroxidase
InVivoPlus rat IgG1 isotype control, anti-trinitrophenol
Immunogen

Recombinant mouse IFN╬│

Reported Applications
  • in vivo IFN╬│ neutralization
  • in vitro IFN╬│ neutralization
  • ELISPOT
  • Flow cytometry
  • Western blot
Endotoxin
  • <1EU/mg (<0.001EU/╬╝g)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Aggregation
  • <5%
  • Determined by DLS
Formulation
  • PBS + 0.01% Tween, pH 8.0
  • Contains no stabilizers or preservatives
Sterility

0.2 ╬╝M filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

Undiluted at 4┬░C in the dark

Murine Pathogen Test Results
  • Mouse Norovirus: Negative
  • Mouse Parvovirus: Negative
  • Mouse Minute Virus: Negative
  • Mouse Hepatitis Virus: Negative
  • Reovirus Screen: Negative
  • Lymphocytic Choriomeningitis virus: Negative
  • Lactate Dehydrogenase-Elevating Virus: Negative
  • Mouse Rotavirus: Negative
  • Theiler's Murine Encephalomyelitis: Negative
  • Ectromelia/Mousepox Virus: Negative
  • Hantavirus: Negative
  • Polyoma Virus: Negative
  • Mouse Adenovirus: Negative
  • Sendai Virus: Negative
  • Mycoplasma Pulmonis: Negative
  • Pneumonia Virus of Mice: Negative
  • Mouse Cytomegalovirus: Negative
  • K Virus: Negative