InVivoMAb anti-mouse TIM-1 (CD365)

Clone Catalog # Category
3B3 BE0289 InVivoMab Antibodies
$95 - $3080
SDS Sheet

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About InVivoMAb anti-mouse TIM-1 (CD365)

The 3B3 monoclonal antibody reacts with mouse T cell immunoglobulin and mucin domain 1 (TIM-1) also known as CD365. TIM-1 is a type I cell-surface glycoprotein and member of the Ig superfamily. TIM-1 is preferentially expressed on TH2 cells and has been identified as a stimulatory molecule for T cell activation. The TIM gene family, plays critical roles in regulating the immune response to viral infection. TIM-1 is also involved in allergic responses, asthma, and transplant tolerance. The 3B3 antibody is an agonistic antibody and has been shown to activate TIM-1 in vivo and in vitro resulting in the hyperproliferation of T cells and induction of proinflammatory cytokine production.

InVivoMAb anti-mouse TIM-1 (CD365) Specifications

Isotype

Rat IgG2a, κ

Recomended Isotype Control(s) InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089)
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Mouse TIM-1 (signal and IgV domains)/mouse IgG2a Fc fusion protein

Reported Applications
  • in vivo TIM-1 activation
  • in vitro T cell stimulation/activation
  • Functional assays
  • ELISA
  • Flow cytometry
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

RRID

AB_2687812