InVivoMAb anti-mouse CD132 (common γ chain)
The 3E12 monoclonal antibody reacts with mouse CD132 also known as the common gamma chain and IL-2 receptor gamma chain. CD132 is a 64-70 kDa type I transmembrane glycoprotein belonging to the Ig superfamily. It is expressed by a wide range of cells including T and B lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential subunit of the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21 receptors. Ligand binding induces tyrosine phosphorylation and initiates signaling through the JAK/STAT pathway. The 3E12 antibody has been reported to block the bioactivity of IL-4, IL-9, and IL-15 and inhibit the ligand/receptor binding of IL-4 and IL-7.
|Recomended Isotype Control(s)||InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin|
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 7.0 Dilution Buffer|
Rat myeloma YB2/0 transfected with mouse cytoplasmic-tailless CD132
0.2 μM filtered
Purified from tissue culture supernatant in an animal free facility
Undiluted at 4°C in the dark