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InVivoMAb anti-mouse E-selectin (CD62E)
Clone Catalog # Category
9A9 BE0294 InVivoMab Antibodies
$300 - 3080

The 9A9 monoclonal antibody reacts with mouse E-selectin also known as CD62E, endothelial-leukocyte adhesion molecule 1 (ELAM-1), and leukocyte-endothelial cell adhesion molecule 2 (LECAM2). E-selectin is a 115 kDa type I transmembrane protein and a member of the selectin family of adhesion molecules. E-selectin is expressed on cytokine-activated endothelial cells. Along with L-selectin and P-selectin, E-selectin mediates the initial interactions of leukocytes and platelets with endothelial cells. E-selectin is thought to play a role in inflammation, tumor metastasis, and angiogenesis. The 9A9 antibody has been shown to reduce the migration efficiency of Th1 cells and block E-selectin-mediated rolling.

Isotype

Rat IgG2B

Recomended Isotype Control(s) InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen

COS-expressed, recombinant mouse E-selectin

Reported Applications
  • in vivo E-selectin blockade
  • in vitro E-selectin blockade
  • Immunohistochemistry (frozen)
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μm filtration

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

Undiluted at 4°C in the dark