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InVivoMAb anti-mouse E-selectin (CD62E)

$ 300.00$ 3,080.00

SKU: BE0294 Categories: ,
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References SDS Sheet

 

InVivoMAb anti-mouse E-selectin (CD62E)

Clone: 9A9 Catalog#: BE0294

Storage:Undiluted at 4C in the dark.
Production:Tissue culture
Isotype:Rat IgG2b
Purification:Protein G
Recommended Dilution Buffer:InVivoPure pH 7.0 Dilution Buffer
Recommended Isotype Control:LTF-2
Reported Applications:in vivo E-selectin blockade
in vitro E-selectin blockade
Immunohistochemistry (frozen)
Endotoxin: <2EU/mg (<0.002EU/μg)

Endotoxin level is determined using an LAL gel clotting test.
Purity: > 95%Purity determined by SDS-PAGE.
Formulation: PBS, pH 7
Sterile: 0.2 μm filtration

Description:

The 9A9 monoclonal antibody reacts with mouse E-selectin also known as CD62E, endothelial-leukocyte adhesion molecule 1 (ELAM-1), and leukocyte-endothelial cell adhesion molecule 2 (LECAM2). E-selectin is a 115 kDa type I transmembrane protein and a member of the selectin family of adhesion molecules. E-selectin is expressed on cytokine-activated endothelial cells. Along with L-selectin and P-selectin, E-selectin mediates the initial interactions of leukocytes and platelets with endothelial cells. E-selectin is thought to play a role in inflammation, tumor metastasis, and angiogenesis. The 9A9 antibody has been shown to reduce the migration efficiency of Th1 cells and block E-selectin-mediated rolling.