InVivoMAb anti-mouse E-selectin (CD62E)
The 9A9 monoclonal antibody reacts with mouse E-selectin also known as CD62E, endothelial-leukocyte adhesion molecule 1 (ELAM-1), and leukocyte-endothelial cell adhesion molecule 2 (LECAM2). E-selectin is a 115 kDa type I transmembrane protein and a member of the selectin family of adhesion molecules. E-selectin is expressed on cytokine-activated endothelial cells. Along with L-selectin and P-selectin, E-selectin mediates the initial interactions of leukocytes and platelets with endothelial cells. E-selectin is thought to play a role in inflammation, tumor metastasis, and angiogenesis. The 9A9 antibody has been shown to reduce the migration efficiency of Th1 cells and block E-selectin-mediated rolling.
|Recomended Isotype Control(s)||InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin|
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 7.0 Dilution Buffer|
COS-expressed, recombinant mouse E-selectin
0.2 μm filtration
Purified from tissue culture supernatant in an animal free facility
Undiluted at 4°C in the dark