InVivoMAb anti-mouse CD200 (OX2)
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About InVivoMAb anti-mouse CD200 (OX2)
The OX-90 monoclonal antibody reacts with mouse CD200 also known as OX2. CD200 is a type 1 membrane glycoprotein belonging to the immunoglobulin superfamily. CD200 expression is limited to thymocytes, neurons, B cells, splenic follicular dendritic cells and endothelium, and subsets of T cells and dendritic cells. CD200 has been shown to co-stimulate T cell proliferation. It is thought that engagement of CD200 with its receptor, CD200R, results in inhibition and/or downregulation of myeloid cell activity. Blocking this interaction decreases the inhibitory thresholds of myeloid cells resulting in increased immune activity. The OX-90 antibody has been reported to block the binding of CD200 to CD200R in vivo.
InVivoMAb anti-mouse CD200 (OX2) Specifications
Rat IgG2a, κ
|Recomended Isotype Control(s)||InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089)|
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 7.0 Dilution Buffer(IP0070)|
Fusion protein consisting of mouse CD200 (extracellular region) and rat CD4 (domains 3 and 4)
0.2 μm filtration
Purified from tissue culture supernatant in an animal free facility
The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.