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InVivoMAb anti-mouse 4-1BB (CD137)

Clone Catalog # Category
17B5 BE0296 InVivoMab Antibodies
$95 - $3080
SDS Sheet

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About InVivoMAb anti-mouse 4-1BB (CD137)

The 17B5 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in several diseases, including cancer. The 17B5 antibody has been shown to block 4-1BB-mediated T cell proliferation in vitro.

InVivoMAb anti-mouse 4-1BB (CD137) Specifications

Isotype

Syrian Hamster IgG

Recomended Isotype Control(s) InVivoMAb polyclonal Syrian hamster IgG(BE0087)
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Not available or unknown

Reported Applications
  • in vitro 4-1BB blockade
  • Flow cytometry
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 µm filtration

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein A

Storage

Undiluted at 4°C in the dark

RRID

AB_2687819