InVivoMAb anti-mouse 4-1BB (CD137)
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About InVivoMAb anti-mouse 4-1BB (CD137)
The 17B5 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in several diseases, including cancer. The 17B5 antibody has been shown to block 4-1BB-mediated T cell proliferation in vitro.
InVivoMAb anti-mouse 4-1BB (CD137) Specifications
Syrian Hamster IgG
|Recomended Isotype Control(s)||InVivoMAb polyclonal Syrian hamster IgG(BE0087)|
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 7.0 Dilution Buffer(IP0070)|
Not available or unknown
0.2 µm filtration
Purified from tissue culture supernatant in an animal free facility
The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.