InVivoMAb anti-mouse IFNγ
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About InVivoMAb anti-mouse IFNγ
The XMG1.2 monoclonal antibody reacts with mouse IFNγ (interferon gamma) a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. IFNγ is primarily produced by activated lymphocytes including T, B, NK cells, and ILCs. IFNγ exerts immunoregulatory, anti-proliferative, anti-viral, and proinflammatory activities and plays an important role in activation, growth, and differentiation of T and B lymphocytes, macrophages, NK cells and other non-hematopoietic cell types. Additionally, IFNγ induces the production of cytokines, Fc receptor, and adhesion molecules and up-regulates MHC class I and II antigen expression by antigen presenting cells during an immune response. IFNγ has also been shown to modulate macrophage effector functions, influence isotype switching and induce the secretion of immunoglobulins by B cells. IFNγ signals through the IFN gamma receptor which exists as a heterodimer composed of CD119 (IFN gamma receptor 1) and AF-1 (IFN gamma receptor 2). The IFNγ receptor is expressed ubiquitously on almost all cell types with the exception of mature erythrocytes. The XMG1.2 antibody is a neutralizing antibody.
InVivoMAb anti-mouse IFNγ Specifications
Rat IgG1, κ
|Recommended Isotype Control(s)||
InVivoMAb rat IgG1 Isotype control, anti-trinitrophenol(BE0290)
InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase(BE0088)
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 8.0T Dilution Buffer(IPT080)|
Recombinant mouse IFNγ
0.2 μM filtered
Purified from tissue culture supernatant in an animal free facility
The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.