InVivoMAb anti-human/monkey CD40L (CD154)
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About InVivoMAb anti-human/monkey CD40L (CD154)
The 5C8 monoclonal antibody reacts with human and cynomolgus monkey CD154 also known as CD40 ligand. CD154 exists as a 39 kDa accessory molecule and belongs to the TNF superfamily of cytokines. CD154 is primarily expressed on the surface of activated CD4+ T lymphocytes but can also be expressed by platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, CD8+ T lymphocytes as well as non-hematopoietic cells including smooth muscle cells, endothelial cells, and epithelial cells. CD154 signals through CD40 and is thought to play a key role in T and B lymphocyte co-stimulation. The 5C8 monoclonal antibody has been reported to block CD40L-CD40 interactions.
InVivoMAb anti-human/monkey CD40L (CD154) Specifications
|Recomended Isotype Control(s)||InVivoMAb mouse IgG2a isotype control, unknown specificity(BE0085)|
|Recommended InVivoPure Dilution Buffer||InVivoPure pH 7.0 Dilution Buffer(IP0070)|
Human D1.1 T cell line
PBS, pH 7.0
0.2 μm filtration
Purified from tissue culture supernatant in an animal free facility
The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.