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InVivoMAb anti-mouse ICOS
Clone Catalog # Category
27A12 BE0226 InVivoMab Antibodies
$350 - 3685

The 27A12 monoclonal antibody reacts with mouse ICOS (inducible T cell co-stimulator). ICOS is a 47-57 kDa homodimeric glycoprotein belonging to the CD28 family of costimulatory molecules. ICOS is expressed on activated T cells and upon ICOSL binding, co-stimulates T and B cell responses. The ligand Is expressed on antigen presenting cells including splenic B cells, dendritic cells, and macrophages. ICOS signaling is also thought to be important for maintaining regulatory T cell homeostasis. The 27A12 antibody is useful for identifying ICOS expressing cells via flow cytometry while the 7E.17G9 anti-ICOS antibody has been shown to block the binding of ICOSL to ICOS in vivo.

Isotype

Syrian Hamster IgM

Recomended Isotype Control(s) InVivoMAb polyclonal Syrian hamster IgG
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer
Immunogen

Mouse ICOS expressing CHO cells

Reported Applications

Flow cytometry

Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

T-Gel

Storage

Room temperature