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InVivoMAb anti-human/monkey CD40L (CD154)

$ 300.00$ 3,080.00

SKU: BE0292 Categories: ,
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Quotes for sizes >100 mg
References SDS Sheet

 

InVivoMAb anti-human/monkey CD40L (CD154)

Clone: 5C8 Catalog#: BE0292

Storage:Undiluted at 4C in the dark.
Production:Tissue culture
Isotype:Mouse IgG2a
Purification:Protein G
Recommended Dilution Buffer:InVivoPure pH 7.0 Dilution Buffer
Recommended Isotype Control:C1.18.4
Reported Applications:in vitro blocking of CD40/CD40L signaling
in vivo blocking of CD40/CD40L signaling
Immunoprecipitation
Flow cytometry
Endotoxin: <2EU/mg (<0.002EU/μg)

Endotoxin level is determined using an LAL gel clotting test.
Purity: > 95%Purity determined by SDS-PAGE.
Formulation: PBS, pH 7
Sterile: 0.2 μm filtration

Description:

The 5C8 monoclonal antibody reacts with human and cynomolgus monkey CD154 also known as CD40 ligand. CD154 exists as a 39 kDa accessory molecule and belongs to the TNF superfamily of cytokines. CD154 is primarily expressed on the surface of activated CD4+ T lymphocytes but can also be expressed by platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, CD8+ T lymphocytes as well as non-hematopoietic cells including smooth muscle cells, endothelial cells, and epithelial cells. CD154 signals through CD40 and is thought to play a key role in T and B lymphocyte co-stimulation. The 5C8 monoclonal antibody has been reported to block CD40L-CD40 interactions.