InVivoMAb anti-human CD19

Clone Catalog # Category
4G7 BE0281 InVivoMab Antibodies
$95 - $3080
SDS Sheet

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About InVivoMAb anti-human CD19

The 4G7 monoclonal antibody reacts with human CD19, a B cell-specific 95 kDa transmembrane glycoprotein of the immunoglobulin superfamily. CD19 contains two extracellular immunoglobulin-like domains and an extensive cytoplasmic tail. It functions as a positive regulator of B-cell receptor signaling in conjunction with CD21 and CD81. CD19 is highly expressed in most lymphomas and leukemias including some early B-cell malignancies that do not express CD20. For these reasons CD19 is quickly becoming an attractive alternative target for the immunotherapy of lymphoproliferative disorders.

InVivoMAb anti-human CD19 Specifications

Isotype

Mouse IgG1

Recommended Isotype Control(s) InVivoMAb mouse IgG1 isotype control, unknown specificity(BE0083)
Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Human chronic lymphocytic leukemia (CLL) cells

Reported Applications
  • Flow cytometry
  • Functional assays
  • Immunofluorescence
  • Chimeric antigen receptor construction (see Poirot, L., et al. reference)
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

RRID

AB_2687804