InVivoMAb anti-mouse NKG2D (CD314) (Clone: CX5)
The LX-CT10.5 monoclonal antibody reacts with human melanoma-associated antigen C2 (MAGEC2), also known as CT10 and HCA587. MAGEC2 is one of many cancer/testis (CT)-antigens. CT antigens are thought to repress the expression of some genes necessary for cellular differentiation. Normally, MAGEC2 expression is restricted to male germ cells in the testis however, MAGE-C2 is abnormally expressed in a wide variety of malignancies, including hepatocellular carcinoma, melanoma, bladder cancer, breast cancer, sarcoma, and lung cancer. MAGEC2 positive tumors are associated with reduced overall survival rates in prostate, hepatocellular, breast, and non-small cell lung carcinomas. Since MAGEC2 is highly expressed in cancer cells but absent from normal adult tissues it is considered an ideal target for cancer immunotherapy. The LX-CT10.5 antibody is useful for identifying MAGEC2 expressing cells in immunohistochemical studies.
This Antibody Is Useful For:
ALWAYS specifically formulated for in vivo use and feature:
Ultra-low endotoxin levels
Preservative, stabilizer, and carrier protein-free
Recommended Control and Buffer:
InVivoMAb mouse IgG2a isotype control, unknown specificity
The C1.18.4 monoclonal antibody is ideal for use as a non-reactive isotype-matched control for mouse IgG2a antibodies in most in vivo and in vitro applications.
InVivoPure pH 7.0 Dilution Buffer
InVivoPure™ dilution buffers are specifically formulated and tested to satisfy the stringent requirements for in vivo applications. They are extremely low in endotoxin, have been screened for murine pathogens, tested in animal models for toxicity and are formulated with respect to buffer composition and pH to satisfy the requirements of Bio X Cell’s antibodies.