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6 posts found

Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

September 6, 2018

    The gut microbiota has been shown to play important roles in maintaining intestinal homeostasis. However, inappropriate immune responses against these bacteria can… Read More

LIGHT-HVEM signaling protects against enteric bacterial infection

August 23, 2018

    It is known that ILCs in the small intestine play a protective role against several mucosal bacterial infections including Yersinia enterocolitica (YE)… Read More

The program for central memory T cell generation is preserved intrinsically in CD8 T cells.

August 10, 2018

  Eun Young Choi’s group from the Seoul National University College of Medicine have discovered that CD4 T cell help is not required to… Read More

TIGIT blockade prevents NK cell exhaustion and elicits potent anti-tumor immunity

July 20, 2018

TIGIT deficiency in NK cells is sufficient to delay tumor growth in vivo and blockade of TIGIT via monoclonal antibodies reverses the exhaustion of anti-tumor NK cells in multiple tumor models and improves overall survival. Read More

Regulatory T cells use lymphotoxin beta receptor to migrate from tissues to lymph nodes

July 10, 2018

    Regulatory T cells use lymphotoxin beta receptor to migrate from tissues to lymph nodes Dr. Jonathan S. Bromberg’s group from the University… Read More

CD40 stimulation drives T cell immunity in cancer

July 1, 2018

    CD40 stimulation drives T cell immunity in cancer Drs. Katelyn Byrne and Robert Vonderheide from the University of Pennsylvania have discovered that… Read More